OEND programs may be supported by multi-faceted programs that provide technical assistance, problem-solving and support through a “hub and spoke” model. In this model, a central (hub) organization is available to provide technical assistance, overdose education and no-cost naloxone to a number of partner (spoke) organizations working in different communities.

A “train the trainer” model can be used to help implement OEND programs. In this model, a primary trainer coaches new trainees in passing on the instructed skills to a subsequent set of individuals. These trainees become trainers themselves of a subsequent round of trainees. This has the dual advantage of improving uptake through simultaneous learning and teaching of OEND programs while also creating self-sustaining OEND programs with the potential for widespread distribution and impact beyond the initial contact point.

Using local champions can help rally a community in support of OEND programs. For this strategy, a central organization partners with local satellites to implement OEND programs and identifies a clinical champion at each local site to serve as a spokesperson and resource for questions and concerns from those delivering OEND as well as those receiving it. Local champions can be effective in reducing stigma and overcoming staff's lack of familiarity with opioid use disorder treatment services.